Cell health & toxicity assays

BioMedha has expertise in the development of cell health assays tailored to client needs and drug discovery project goals using normal or disease-relevant, immortalised or iPSC derived cell models. We offer complete support from assay development to compound profiling for identifying drug effects on cell health, ranking compounds for potency and investigating the cellular changes in disease areas such as cancer, autoimmune disease and neurodegeneration. Screening platforms include:

  • Cell viability, cell proliferation and cytotoxicity assays
  • Apoptosis and Pyroptosis (an inflammatory form of programmed cell death)
  • Phagocytosis, Mitophagy and Autophagy
  • Oxidative stress and Hypoxia
  • Cell adhesion assays
  • Cellular energy metabolism assays (Glucose uptake, NAD co-factor)
  • Metabolite assays (Glucose and Glutamine consumptions; Lactate and Glutamine secretion)
  • Lipid peroxidation and Phospholidosis
  • HepG2 cytotoxicity
  • Cyp, Pgp and UGT activity
  • hERG  activity: FP based assay