Expression Studies

Expression studies with normal and diseased models may provide better understanding of associated pathways and disease biology. Compound profiling for drug effects on target expression can help to gain insights into drug interactions with targets, therapeutics efficacy and any associated drug toxicity. Expression studies include:

  • Target expression levels and compound profiling
  • Assay formats: Western blotting, qPCR, ELISA, HTRF and AlphaLisa
  • Transfections (transient/ stable) and transductions
  • Transcription factor-activation profiling specific to project (e.g., cancer,  neurodegenerative, T-cell activation, insulin resistance)
  • Sample type: cells, blood and tissues (e.g., from xenograft studies)