Expression Studies

Expression studies with normal and diseased models may provide better understanding of associated pathways and disease biology. Compound profiling for drug effects on target expression can help to gain insights into drug interactions with targets, therapeutics efficacy and any associated drug toxicity. Expression studies includes:

  • GENE expression by qPCR
  • Total PROTEIN levels by Western blotting
  • SECRETION levels by ELISA/ AlphaLisa/ HTRF/ Luminex
  • SURFACE EXPRESSION by Flowcytometry
  • Transcription Factors activation
  • Target validation (In vitro)
  • Measuring compound effect on target
  • Biomarker levels
  • Sample type: cells, blood, and tissue (e.g. xenograft)
  • Species: Human, Rat, mouse, and dog