In vitro primary cell assessment plays a critical role in the progression of early-stage drug discovery and development. Evaluating the immunomodulatory effects of test compounds is a service we provide to expedite the translation of your drug candidates into the clinic.

We have access to fresh whole blood, which we use to isolate primary immune cells for the development of preclinical assays for compound testing. Our standardized assays, developed by in-house experts, are optimized to meet client project needs.

Immunology assay services include:

• Isolation of immune cells from fresh whole blood: PBMCs, monocytes, T cells, CD4+, CD8+, B cells, NK cells, neutrophils, dendritic cells, granulocytes and lymphocytes
• Whole blood assays
• Cytokine release assays/ Luminex Multiplexing assays
• Monocyte differentiation into dendritic cells and macrophages
• T cell activation, differentiation and TLR response
• Immunogenicity / Cytokine storm: Multiplexing assays against multiple donors
• Proliferation and cytotoxicity
• Chemotaxis/ Migration assays
• NETosis studies
• Immune Checkpoint Bioassays
• ADCC assays
• Immune Cell Death
• T cell killing assays vs tumor cells
• Expression studies: mRNA levels and protein levels
• Co-cultures

Contact us to find out more about the immunological tools we have and how we can accommodate your project-specific needs.