Cytokine storm assay (Immunogenicity)
Cytokine storm assay (Immunogenicity) In vitro assay using PBMCs isolated from healthy donor whole blood. Suitable as a predictive model for immunogenicity risk assessment (Cytokine storm). Assay utilises Luminex multiplexing magnetic bead-based assay detection. Figure-A: Concentration of each Cytokine analyte (pg/mL) in PBMC supernatant from eight-donors. Data was plotted as y-axis (cytokine levels in pg/ml) […]
Biomarker assays: analysis of ex-vivo samples
Biomarker assays: analysis of ex-vivo samples Ex-vivo sample analysis provides a means to confirm the in-vivo effect of test compounds and to identify the correlation between in vivo efficacy and biomarkers. In this study, ex-vivo rat and mouse plasma samples, and human plasma from healthy donors were analysed for cytokines as biomarkers. Rat plasma (ex-vivo) […]